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Castleman´s disease, or angiofollicular lymph node hyperplasia, is a rare tumor of lymphoid origin, of unknown etiology. The expected localization is mediastinum, but rarely retroperitoneum. Localized and multicentric Castleman´s diseases may be different clinical disorders, but with overlapping histological features. Recently, we experienced three cases of Castleman´s disease. One case was a mixed variant, which presented as a right perirenal mass in a 23-year-old woman. The lesion was detected incidentally on computerized tomography (CT) and successfully resected. The remaining two cases were multicentric, plasma cell variants of Castleman´s disease, which presented as an inguinal mass in a 29-year-old male, and as a multiple neck lymphadenopathy in a 63-year-old male, respectively. Although Castleman´s disease in the perirenal retroperitoneum is extremely rare, accounting for only 2% of all reported cases, it should be included in the differential diagnosis of the mostly malignant retroperitoneal masses. We suggested that radical surgery may be avoided, given the excellent outcome after a limited excision in solitary retroperitoneal Castleman´s disease.
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